In a murine model of allergic rhinitis (AR), administration of IL-37 decreased the number of eosinophils in the nasal mucosa, restored its thickness, lowered the frequency of nasal rubbing and sneezing, and decreased the levels of immunoglobulin (Ig)E, IgG1, IgG2a, IL-4, IL-13, IL-17a, and C-C Motif Chemokine Ligand 11 (CCL11), which recruits eosinophils [51]. This evidence concerns the gene IGHE and allergic rhinitis.