In this investigation of the ischemic model of Alzheimer’s disease, we extended our previous studies on the deleterious effects of genes related to the metabolism of amyloid protein precursors and changes in tau protein on changes in the expression of genes related to amyloid transport (LRP1 and RAGE), in order to deepen our understanding of the etiology of Alzheimer’s disease. The gene discussed is LRP1; the disease is Alzheimer disease.