LRP1 and early-onset autosomal dominant Alzheimer disease: Furthermore, LRP1 is an endocytic receptor that transports ligands from the cell surface to the endosomal compartment, where the ligands are typically sorted into the lysosomal compartment and degraded, suggesting the dual involvement of LRP1 in Alzheimer’s disease development [27] and possibly in post-ischemic brain neurodegeneration.