While both AD models in our study, 5xFAD and APP23, are associated with an altered neurogenesis prior to disease pathology, we showed that increased Tpr expression in DCX+ hippocampal neuroblasts precedes increased neurogenesis and that misregulation of Tpr in NSPCs correlates with altered NPC numbers in 5xFAD mice. The gene discussed is DCX; the disease is Alzheimer disease.