SOD1 and amyotrophic lateral sclerosis: In this paper, we used primary cultures of myoblasts derived from muscle precursor cells of newborn mice to study in vitro myogenesis, allowing us to confirm previous findings of impaired myogenesis in different ALS models, such as C2C12 cells overexpressing SOD1(G93A) or mutant SOD1 iPSC-derived myotubes [31,39,54,67].