Starting from previous findings showing ALS-related alterations in myogenesis [39,40,54], we decided to evaluate morphometric parameters and the expression of the differentiation marker myosin heavy chain-embryonic (EmbMyHC) in primary cultures derived from hSOD1(G93A) mice and the hSOD1(WT) counterpart. This evidence concerns the gene SOD1 and amyotrophic lateral sclerosis.