In difficult-to-treat asthma in humans, an increase in Th17 cytokines causes the upregulation of glucocorticoid receptor-beta (GR-β) [157,158], contributing to the dysregulation of the GRα/GRβ ratio [159] and disrupting GC binding to GR and its translocation to the nucleus. The gene discussed is GZMB; the disease is asthma.