BRCA1 and neoplasm: In addition, hydrogen peroxide generated by ovarian cancer cells lacking BRCA1 also induces mitophagy by activating the nuclear factor kappa-light-chain-enhancer of activated B cell (NFκB) signaling, which is known for suppressing BRCA1, a tumor suppressor gene that maintains genome integrity and suppresses tumors by activating NFκB signaling in stromal cells.