In addition to ROS, cytokines or physiological factors enriched in the tumor microenvironment, such as the migration stimulating factor (MSF), a genetically truncated N-terminal isoform of fibronectin, can also induce mitophagy in tumor stromal cells by activating TGF-β and CDC42- NFκB signaling [176]. The gene discussed is FN1; the disease is neoplasm.