An E3 ubiquitin ligase, NEDD4L, inhibits ULK1 in pancreatic cancer cells by deregulating its protein stability and reduces tumor cell growth by exhibiting the opposite effects between ULK1 expression in the KPC mouse model and the xenograft mouse model of shNEDD4L cells [50]. The gene discussed is ULK1; the disease is familial pancreatic carcinoma.