In addition, integrin beta 4 (ITGB4)-overexpressing triple-negative breast cancer (TNBC) cells provide the cancer-promoting capabilities of CAFs with ITGB4 proteins via exosomes, thus enhancing BNIP3L-dependent mitophagy and producing more lactate in CAFs [150]. This evidence concerns the gene ITGB4 and triple-negative breast carcinoma.