SERPINE1 and cancer: In BC cells, HMGA1 knockdown induced a cobblestone-like morphology in MDA-MB-231 cells [86], while reducing the secretion of several proteins associated with decreased cancer relapse and distant metastasis-free survival [e.g., Serpin E1 (SERPINE1) and Plasminogen activator, urokinase (PLAU)] [87].