TGFB2 and neoplasm: Interestingly, TGF-β2 increased the expression of the tumour protein p53-inducible nuclear protein2, the knocking down of which blocked TGF-β2-induced autophagy and EMT, suggesting that tumour protein p53-inducible nuclear protein2 is a downstream regulator of autophagy flux induced by TGF-β2 and represents a novel target for the treatment of posterior capsular opacification [84].