CD4 and congenital rubella syndrome: Rats exhibited depressive-like symptoms, BBB disruption, and neuroinflammation in the dorsal striatum. There was also a time-dependent increase in thymus- and spleen-derived CD4+ T cells. Inhibition of CD4+ cell differentiation with SR1001 in the early stages of CRS exposure ameliorated stress-induced depressive-like behavior and the inflammatory response