In another study, the use of an anti-α5 antibody on three colon-cancer-cell lines (KM20, KM12C, and KML4A) reduced their adhesion capacity and induced apoptosis related to a decrease in the expression of phosphatidylinositol-3-kinase (PI3K) activity, the latter of which participates in cell proliferation and survival pathways [46]. This evidence concerns the gene PIK3CA and colonic neoplasm.