Reports indicate that plant nutraceuticals can combat breast cancer by reducing breast cancer severity, restricting malignant cell growth, and modifying cancer-related mechanisms such as the attenuation of Hedgehog, Nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB), Notch, and Wnt/β-catenin signaling as key signaling pathways involved in breast CSCs self-renewal [12,13]. This evidence concerns the gene NFKB1 and breast cancer.