Human loss-of-function mutations in a number of actin-regulatory proteins, including the Wiskott–Aldrich syndrome protein (WASp), the WASp-interacting protein (WIP), the Arpc1B subunit of the Arp2/3 complex, Wdr1, Hem1, and DOCK8 lead to immune dysfunction syndromes that have been termed ‘actinopathies’ [16,17,18,19,20,21]. Here, WIPF1 is linked to alpha-actinopathy.