BDNF and age-related macular degeneration: Some other studies depicted the positive ophthalmic effects of higher physical activity, including neuro-protectivity through brain-derived neurotrophic factor (BDNF) signaling [100], increasing macular choroidal thickness [101], lowering the risk of AMD [102,103], and decreasing IOP and the need for the retinal photocoagulation treatment of DR [97,104].