H19 and pulmonary arterial hypertension: Human: - ↑ H19 and mir 675 in PAH DRV. - H19 correlates with RV fibrosis and CM hypertrophy. - ↑ H19 in blood of PAH DRV patients. - Circulating H19 is an independent predictor of survival. In vivo:- targeting H19 improves RV function, ↓ RV fibrosis in MCT and PAB rats. In vitro: - si H19 => ↓ CM hypertrophy and expression of cardiac stress genes - adv H19 and mimic-675 has the opposite effect.