SMURF1 and coronary artery disorder: Human:-PH patients vs. Ctrl = ↑ miR-424(322) - miR-424(322) corelates with symptoms and hemodynamics - miR-424(322) predicts survival in CHD-PH.In Vivo:- association between circulating miR-424(322) levels and RV hypertrophy- RV miR-424(322) correlates with ↓ SMURF1 expression In Vitro: - hypoxia induces the secretion of miR-424(322) by PAECs, which after being taken up by cardiomyocytes leads to down-regulation of SMURF1.