SIRT1 and diabetic kidney disease: Activated p53 signaling under DKD models was found to impair autophagy response in renal tubular cells via the unc-51-like autophagy-activating kinase 1 (ULK1) pathway [20], and in podocytes via the nutrient-sensing Sirtuin-1 (SIRT1) pathway, leading to subsequent DKD progression [21].