SCD and glioblastoma: Finally, lipidomics showed that fatty acid desaturation, which promotes membrane fluidity, contributes to stemness preservation in ovarian and glioblastoma CSCs [126,127], and the regulation of this process by stearoyl-CoA desaturase (SCD1), NF-κB, and aldehyde dehydrogenase I family member A1 (ALDH1A1) promotes stemness in colorectal CSCs [128,129].