The results of this research showed that the usage of the intracellular survival signaling pathway inhibitors PI3K-Akt/PKB-mTOR and Ras-Raf-MEK-ERK in simultaneous application resulted in the formation of Bcl-2 and beclin-1 complexes, which was correlated with induction of apoptosis in glioma cells. Here, BECN1 is linked to glioma.