C2 and age-related macular degeneration: Regarding the overlap of our DSGs with previously reported AMD loci [7,29,30,52,53,54,55,56,57,58,59], CFB and FLT1 were up regulated while C2 and CLUL1 were downregulated in the macular RPE/choroid of iAMD vs. normal (padj < 0.05).