Ozone modulates oxidative stress through the activation of the Nuclear Factor Erythroid 2-Related Factor 2 (Nrf2) pathway in cells [18,19,20] and then induces the synthesis of cytoprotective proteins, which favors cell survival and improves the oxidative stress in the intervertebral disc degeneration [5,20]. The gene discussed is NFE2L2; the disease is Intervertebral disk degeneration.