In addition to hepatitis B and hepatitis C also associated with HCC in adults, various genetic diseases are known to constitute predisposing conditions for the development of pediatric HCC, such as glycogen storage disease, tyrosinemia, Alagille syndrome, alpha1-antitrypsin deficiency, and progressive intrahepatic familial cholestasis type 2 [2,78,79]. This evidence concerns the gene SERPINA1 and hepatocellular carcinoma.