Thus, for establishing the model, we operated with the following predictors: age, arterial hypertension, diabetes mellitus, baseline GFR, 6WT measured at visit 4, BNP values measured at visit 4, LVEF levels at visit 4, i.e., nine months after the treatment onset, total dose of irradiation received, and anthracycline cumulative doses. The gene discussed is NPPB; the disease is diabetes mellitus.