For example, a 70-year-old patient (4 points) with arterial hypertension (26 points) and diabetes mellitus (11 points), with a GFR of 82 mL/min/1.73 m2 (17.5 points), who performed a 368 m 6WT (13 points) at visit 4, with a BNP value at visit 4 of 93 pg/mL (19 points), an LVEF level at visit 4 of 57% (57.5 points), and a cumulative dose of doxorubicin 675 mg/kg (42 points), with a total dose of preceding radiation treatment 46 Gy (12.5 points), scored in sum 202.5 points. Here, NPPB is linked to Hypertension.