Among these SNPs, rs1053005 A/G SNP in the 3′ untranslated region of STAT3 mRNA was identified as a Hyper-IgE recurrent infection syndrome 1 susceptibility locus, which is responsible for many autoimmune disorders such as Grave’s disease and Hashimoto thyroiditis [48,49,50]. The gene discussed is STAT3; the disease is Graves disease.