The results of the statistical variance analysis (ANOVA) for biochemical parameters of malignant and nonmalignant lymphocytic pleural effusions (CRP, LDH, pleural effusion, and serum proteins) yielded statistically significant differences in the mean values of the biochemical parameters for serum (s) and pleural fluid (p) proteins (p < 0.01). The gene discussed is CRP; the disease is Pleural effusion.