Terminally exhausted CD8+ T cells are more likely to accumulate in tumors with higher levels of immunosuppression after ICB, such as squamous cell carcinoma (SCC), basal cell carcinoma (BCC), and RCC, while precursor-like CD8+ T cells tend to accumulate in tumors with lower levels of immunosuppression, such as NSCLC and melanoma [102, 106]. Here, CD8A is linked to melanoma.