While biomarkers such as PD-L1 expression [3], mismatch repair deficiency (dMMR) or microsatellite instability-high (MSI-H) [4], and tumor mutational burden (TMB) [5] are routinely utilized to identify people who may benefit from immune checkpoint blockade (ICB), these methods are not always accurate in predicting response to ICB in clinical practice. The gene discussed is CD274; the disease is neoplasm.