CD8A and cancer: Similarly, Khojandi et al. [101] also observed a significant decrease in naïve-like gene expression in peripheral CD8+ T cells after ICB, such as TCF7, SELL, IL7R, and CCR7. Collectively, scRNA-seq reveals that CD8+ T cells can shift from the naïve state to a more activated state during ICB, characterized by the expansion of effector cells and increased cytotoxic activities against cancer cells.