HAND2 and dilated cardiomyopathy: Several PSGs in this over-represented set, however, have specificities to cardiovascular and pulmonary function; for example HAND2 and SGCG belong to the dilated cardiomyopathy KEGG pathway [50, 51] and epinephrine-binding receptor ADRA2B is a key gene in studies of broncho- and vasodilation in response to exercise in humans [52].