In the adult population, at least five independent research groups have identified sepsis subgroups describing an adaptive immunity suppression phenotype with corresponding higher mortality such as Scicluna et al.’s MARS1 endotype [27], Davenport et al.’s SRS1 subgroup [28], and Sweeney et al.’s Inflammopathic subtype [29–31]. This evidence concerns the gene MARS1 and Sepsis.