INS and type 2 diabetes mellitus: In patients with T2DM (50–58 years old) with 60% already taking antidiabetic drugs, the addition of daily acarbose (100 mg 3 times per day) and 12 weeks of moderate-intensity aerobic exercise yielded improvements to fasting glucose, HbA1c, insulin sensitivity, HbA1C, and VO2max while exercise alone was only capable of improving insulin sensitivity [200].