Another report conversely showed that hypoxia causes TG accumulation by HIF-1α-mediated stimulation of lipin 1 expression in Huh7 HCC cells, whereby hypoxia-induced lipin 1 can accelerate conversion of phosphatidic acid to diacylglycerol (DAG) in TG synthesis [44]. The gene discussed is HIF1A; the disease is hepatocellular carcinoma.