IFNB1 and hepatocellular carcinoma: The effect of IFN-β on the remaining cell lines was more intermediate, with Hep3B showing least of an impact despite being a well-differentiated hepatoma cell line, and both SNU387 and SNU182 exhibiting a slightly stronger growth inhibition than PH5CH despite being fibroblast-like and, at least SNU387, higher malignity in our assays (Fig. 4a).