Meanwhile, Bacterial and viral infection related pathways were similarly enriched including Shigellosis, Salmonella infection, Human T-cell leukemia virus 1 infection, Hepatitis B, Yersinia infection, Fc gamma R-mediated phagocytosis, C-type lectin receptor signaling pathway and Acute myeloid leukemia, which may reflect dysfunction of the immune system reported in DS. This evidence concerns the gene CLEC4D and shigellosis.