The genotypic frequency of VDR rs2228570 in HCV cirrhotic and HCC patients had a high prevalence of CC genotype compared to healthy control (OR = 2.279; CI: 1.283–4.033, p < 0.01, OR = 1.685; CI: 0.951–2.985, p < 0.05), respectively. The gene discussed is VDR; the disease is hepatocellular carcinoma.