The involvement of VDR SNPs in HCC development was reported in several populations [17–23] with fluctuating data, but a few VDR SNPs have been examined concerning HCC risk factors in the Egyptian population [24–27], however, it is still unclear in Egyptian patients whether VDR and DBP SNPs could be risk factors in chronic HCV-infected HCC patients. This evidence concerns the gene VDR and hepatocellular carcinoma.