To validate this hypothesis, we employed the CTCF-based 3D chromatin interaction data from two prostate cancer cell lines, 22Rv1 and VCaP, as well as the prostate epithelial cell line RWPE-1 to examine the spatial relationship among eCpG, eGene, and eSNP (“Methods”). The gene discussed is CTCF; the disease is prostate carcinoma.