ACKR3 and breast cancer: For BC patients with stage III-IV, we noticed a higher expression level of ACKR3 and THY1 compared to those with stage I-II (Fig. 2E); For BC patients with N1-3, we noticed a higher expression level of ACKR3 and THY1 compared to those with N0 (Fig. 2F); For BC patients with T3-4, we noticed a lower expression level of MMP13 and COL11A1 compared to those with T1-2 (Fig. 2G); No significant difference was observed in the M stage (Fig. 2H).