Treatment with EgCF significantly reduced the expression of TLR2 and MyD88 in the liver (ANOVA: F(4, 10) = 23.56, P < 0.0001; F(4, 10) = 26.47, P < 0.0001, respectively), kidney (F(4, 10) = 50.64, P < 0.0001; F(4, 10) = 31.66, P < 0.0001, respectively) and lung (F(4, 10) = 44.01, P < 0.0001; F(4, 10) = 14.69, P < 0.0001, respectively) of mice with CLP-induced sepsis relative to the septic mice without treatment (Fig. 9a–c). The gene discussed is MYD88; the disease is Sepsis.