After being treated with EgCF, the expression levels of TLR2 and MyD88 in those key organs (liver, lung, and kidney) of mice with CLP-induced sepsis were significantly reduced (Fig. 9), indicating the anti-inflammatory effect of EgCF on the sepsis is through inhibiting TLR-2 and MyD88 inflammatory signaling pathway. This evidence concerns the gene MYD88 and Sepsis.