While nearly all chemotherapy drugs can enhance GSDMC expression and promote nPD-L1 translocation, specific antibiotics, such as daunorubicin, doxorubicin, epirubicin, and actinomycin-D, have been shown to activate caspase-8 and then cleave GSDMC, initiating pyroptosis in cancer cells. This evidence concerns the gene GSDMC and cancer.