GSDMD and neoplasm: As enhancer deregulation has been demonstrated to be associated with oncogenesis, Ning and colleagues found that deletion of mixed-lineage leukemia 4 (MLL4), an enhancer-associated histone H3 lysine 4 mono-methyltransferase, has the potential to heighten anti-tumor immunity by inducing GSDMD-mediated pyroptosis and transcriptional reactivation of the double-stranded RNA-interferon response.