Immunotherapy resistance observed in cold tumor may be related to impaired antigen processing (Human leukocyte antigens (HLA) and/or β2 microglobulin loss or downregulation, and elimination of neoantigens through copy-number loss), loss of T-cell priming mainly because of the inhibition of T cells generation by DCs in desert tumor, or the absence of preexisting antitumor T cells infiltration (T-cell-excluded tumors) [15]. The gene discussed is HLA-G; the disease is neoplasm.