In the respiratory system, RGS6 was found to suppress TGF-β-induced epithelial–mesenchymal transition in vitro, and TGF-β was found to promote metastasis in vivo through canonical TGF-β-SMAD signaling in non-small cell lung cancer (NSCLC) [28]. This evidence concerns the gene TGFB1 and non-small cell lung carcinoma.