FTO-mediated m6A modification can upregulate lncRNA ENST00000436340, enhancing the binding of PTBP1 to its target gene RAB3B by interacting with the PTBP1 protein and promoting degradation of RAB3B mRNA, which mediates cytoskeletal rearrangement and inhibits GLUT4 translocation, which leads to podocyte injury and DN progression (Hu et al. 2023). The gene discussed is FTO; the disease is liver dysplastic nodule.