TREX1 and autoimmune disease: In this study, we found that the active component of Glabridin in licorice flavonoids can inhibit the cGAS-STING signalling pathway both in vivo and in vitro and exert therapeutic effects in autoimmune diseases mediated by Trex1−/−, and also provide a reference for the use of Glabridin in the treatment of autoimmune diseases mediated by the cGAS-STING pathway.