The disease-related signature enrichment overview (Fig. 6) based on 344 metabolite sets reported in human blood using metaboanalyst showed a significant resemblance between the NC and BN treatments for transaldolase deficiency, propionic acidemia, hypertension, 3-phosphoglycerate dehydrogenase deficiency, patent ductus venosus, phosphoserine aminotransferase deficiency, and sotos syndrome. Here, PSAT1 is linked to hyperinsulinemic hypoglycemia, familial, 4.