Concerning FGFR, all cases displayed FGFR1 hotspot substitutions N546K/D (73%, 27/37) and/or K656E/M (23%, 11/37) preferentially occurring in CNS tumours, but neither FGFR1 fusion/duplication nor FGFR2/3 alterations (Fig. 1) [20]. Here, FGFR1 is linked to central nervous system neoplasm.