Using unsupervised analysis of DNA methylation tumour profiles, DMG_K27-BRAF/FGFR1 formed a specific cluster, separated from other DMG_K27 gliomas, others adult/paediatric diffuse gliomas, low-grade glial/glioneuronal tumours and more specifically BRAFV600E-mutated ganglioglioma even midline located. This evidence concerns the gene BRAF and central nervous system cancer.