Additionally, KDM5B has been reported to characterize a slow-cycling cell subpopulation in melanoma [25], which fits the traits of supercluster A. Supercluster B, the least proliferative, is also the one with the strongest expression of canonical EMT markers/TFs such as FN1, SNA1, MYC, and SOX9. When compared to superclusters A and C, DEGs from supercluster B appear to be under the control of HEY2, a member of the basic helix-loop-helix (bHLH) transcription factor family. This evidence concerns the gene HEY2 and melanoma.