PAX5 and acute lymphoblastic leukemia: We initially screened our cohort for the molecular ALL subtypes outlined by the International Consensus Classification (ICC)2 using a combination of genome-wide CNA detection, fusion gene screening (Supplementary Fig. 1), and targeted mutational assessment for PAX5 p.Pro80Arg, IKZF1 p.Asn159Tyr, and ZEB2 p.His1038Arg (Supplementary Data 2).