Loureirin C was recently shown to improve cognitive impairment in Alzheimer’s disease genetically modified mice via estrogen receptor α (ERα)44, while stemwood extract of DL prevented amyloid-β (Aβ) fibril formation and disassembled Aβ aggregation, leading to reduced Aβ-induced neuronal toxicity7. The gene discussed is ESR1; the disease is early-onset autosomal dominant Alzheimer disease.