Analysis of colon adenocarcinoma (COAD) primary tumor TCGA datasets revealed that high SLC6A14, SLC12A4 or SLC25A15 expression when evaluated individually are not predictive of overall survival; however, when coexpression of two SLCs of interest were evaluated, patients with high SLC6A14 and high SLC12A4 had significantly shorter survival than those with high SLC6A14 and low SLC12A4 (Extended Data Fig. 7a), suggesting a potential functional link and predictive signature for these two transporters. The gene discussed is SLC12A4; the disease is colon adenocarcinoma.