Analysis of the TCGA to understand the relationship between CNV status, mRNA level, and protein expression for cyclin D1 in patients (n = 89 with RPPA information available) with superficial spreading melanoma (CDK4 and CDK6 protein expression unavailable) also revealed no correlation between gene copy number or mRNA expression with protein expression (Supplementary Fig. 1G). The gene discussed is CCND1; the disease is melanoma.