Further exploration through protein–protein interaction (PPI) analysis led to the identification of a select group of 10 hub genes, ADRB2, ACTB, ARRB2, GNGT2, ADRB1, ACTG1, ACACA, ATP5A1, ADCY9, and ADRA1B, each of which plays a pivotal role in the context of lung cancer, as indicated by MCC analysis. Here, ATP5F1A is linked to lung cancer.