Most importantly, a significant interaction between AKI and VKORC1 (INTadd mean − 1.17, 95% CI − 1.82 to − 0.53) was observed (p = 0.0004), and the additive influence of AKI plus VKORC1 morphism on average daily dose was statistically weaker than the sum of adding each individually. This evidence concerns the gene VKORC1 and acute kidney injury.