After several algebras, the INTadd involving AKI and CYP2C9 finally is expressed as Eq. (5).5\documentclass[12pt]{minimal}\usepackage{amsmath}\usepackage{wasysym}\usepackage{amsfonts}\usepackage{amssymb}\usepackage{amsbsy}\usepackage{mathrsfs}\usepackage{upgreek}\setlength{\oddsidemargin}{-69pt}\begin{document}$$\left( {Cl_{{{\text{int}} ,2c9,AKI}} - Cl_{{{\text{int}} ,2c9}} } \right)\int {C_{f} dt - \left( {Cl_{{{\text{int}} ,c}} - Cl_{{\text{int}}} } \right)} \int {C_{f} dt}$$\end{document}Clint,2c9,AKI-Clint,2c9∫Cfdt-Clint,c-Clint∫Cfdt. This evidence concerns the gene CYP2C9 and acute kidney injury.