While corelating labelling index and H- score of PD-L1 positive tumour epithelial cells with labelling index and H-score of PD-1 positive TILs, we could obtain statistically significant results (p value of 0.005 and 0.001).Correlating the PD-L1/PD-1 positivity, we could infer that T-cell inactivation occurs in the microenvironment at the invasive front and is possibly involved in cancer progression. The gene discussed is RPL17; the disease is cancer.