Although more patients had predominantly lepidic or papillary adenocarcinoma, the patients with solid-predominant adenocarcinoma were significantly more positive for PD-L1 and CD155 than those with the other adenocarcinoma subtypes (both p < 0.0001) based on a TPS of 5% or higher in a previous study15. This evidence concerns the gene PVR and papillary adenocarcinoma.